An analysis of commercial aircraft damage due to weather related wind shear may show side loading, rather than G forces, are the cause of excessive stress. Looking at a = f/m, one can see with a very large plane will almost behave as a fixed object in wind shear, and leveraging of forces presents the greatest danger.
This was the demise of many of the great airships in the 1920s, when they made a serious bid at transatlantic passenger and mail service and were considered for military applications as well. Those unlucky enough to get caught in severe weather were literally torn in half by wind shear. Their great size worked against them.
These incidents are much rarer in modern times, as faster flying jets are much stronger. But designers should be aware of the weaker points, and pilots should avoid weather conditions that may exceed them.