The Boeing 727 had the distinction of a rear doorway with stairs that could be lowered so that passengers could embark and disembark at rural airports which did not have their own airstairs. 

The highjacker [DB Cooper][1] famously used the rear door to make his parachute escape mid-flight.

![727 ejecting DB Cooper][2]

 In the wake of this, the FAA mandated in 1972 that [cooper vanes][3] to be installed to prevent the opening of the rear door while in flight.

Does this make the pre-cooper 727 the last passenger airliner whose doors (either passenger or cargo) could be normally opened while in flight? 

<sub>Animated image from wikipedia and cc.</sub>