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The DC-4 was a totally new design in all respects, as can be seen from the planform diagrams (wiki)

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The DC-4 was larger, and structurally totally different:

  • Straight tapered wing (no sweepback)
  • Straight tubular fuselage, not the aerodynamic teardrop shape
  • Round fuselage cross-section. The original DC-4E was going to have a pressurised cabin. The later DC-4A did not implement this but retained the circular cross section necessary for pressurisation.
  • MTOW = 33,100 kg for the DC-4, 11,430 kg for the DC-3
  • Four engines of 1,081 kW each, while DC-3 had 2 engines of 890 kW each.

All in all a larger aircraft, designed from scratch.