The Boeing 727 had the distinction of a rear doorway with stairs that could be lowered so that passengers could embark and disembark at rural airports which did not have their own airstairs.
The highjacker DB Cooper famously used the rear door to make his parachute escape mid-flight.
In the wake of this, the FAA mandated in 1972 that cooper vanes to be installed to prevent the opening of the rear door while in flight.
Does this make the pre-cooper 727 the last passenger airliner whose doors (either passenger or cargo) could be normally opened while in flight?
Animated image from wikipedia and cc.