In recent news here in England was the case of a female passenger on a flight I think London to Antalya, who got a bit out of control, and decided she wanted to leave the airplane and tried to open the cabin door - in mid flight. I couldn't identify the plane, but just an average plane used by holidaymakers.
This would obviously frightening for everyone, but would there be actually any chance that she succeeds? If she was not an average woman but an unusually strong man? If she worked on other flights and had knowledge how to open cabin doors. that the average passenger doesn't have, but no keys etc. that would be needed on that flight?