In the comments on this answer an interesting assertion was made, that you never have a situation in the US where there is no possible alternate airport. Assuming that:
- you're flying an aircraft that is normally flown for commercial reasons,
- you're flying to an airport that normally allows flights to land,
- you're flying from an airport in the US to another airport in the US,
- and you're following the regulation that you have to have enough fuel to get to your destination, then fly to your alternate, then stay in the air for another 45 minutes
is there any combination of aircraft and airports where no alternate landing airport would be possible?