Many might not like my answer, but from my perspective, its as follows.
Even if the aircraft loses all these wing fasteners, nothing will happen to the aircraft. Unless the loose panels or nuts find their way into the engine/Jet.
The wings are welded and form the primary structure of the aircraft, like a skeleton. These panels cover the Fuel tanks, Anti Freeze systems, Wiring, Mechanicals to the ailerons, mechanical cables, rods, radar and other systems installed in the wings. In addition, these panels aid in drag reduction, which helps with fuel efficiency.
If an aircraft loses any of such panels in flight, it just increases the drag and causes minor imbalance, when the crew need to act and reduce the speed accordingly to ensure no additional damage is caused to the internal materials. In most commercial aeroplanes, it mightn't cause drag too, because the wings shape is designed in such a way, there is no pressure on the wing from the top. The front end of the wing will be thicker and the thickness tapers down by the edge, where the wing meets the flaps.