Moving the thrust (and additional weight) to the wingtips creates more drawbacks than benefits.
Yaw - because of the increased moment of inertia (compared to having the engines be closer to the fuselage - the center line of the mass), it would be harder to initiate yaw changes as well as harder to stop or reverse them. Left/right thrust differentials could be used, and that would certainly increase yaw change rate, but then you have to consider the time cost of changing the force of each engine quickly. And it becomes a very serious problem if you have a failure on one side, leaving you with only one wingtip generating all of the thrust. Depending on the geometry of the aircraft and the size of the vertical stabilizer, it might not even be possible to counter the yaw force generated by the one engine producing enough thrust to keep the aircraft flying.
Roll - Similar to the yaw problem, the roll rate would be reduced the further the weights were moved away from the center line.
The V-22 Osprey is an example of this design. The wings are kept short to minimize the increase to moment of inertia, but the operational requirements of the vehicle (VTOL) required it to have large propellers (rotors), so the wings had to be long enough to keep the prop tips from hitting the fuselage.
Additionally, vibration and external (turbulence) effects on the wing structures would have to be considered. Even in normal operating conditions, the wings would be subject to increased vibrations that could create structure failures in some complex compound wave situations. Aircraft designers already deal with this and model these scenarios, but the complexity increases (I suspect exponentially) as the vibrational force is moved further toward the wingtip.