Most multi-engine aircraft have engines that rotate the same direction on both sides of the fuselage (e.g. the GEnx rotates clockwise, as viewed from the front, there is no 'mirrored' version).
What would the effect (drag, stability, turning performance) be, if an aircraft were to have oppositely-turning engines on each side of the aircraft (especially if the engines were rotating counter to the wingtip vortices)?
Note that propeller and jet engines may have significantly different answers!