Mechanically it is difficult, although moving more air with lower rpm props has the possibility of improving thrust efficiency per horsepower.
Keep in mind, while this approach certainly benefited the Wrights 30 to 50 mph craft, slower rpm props will more rapidly lose thrust efficiency as forward speed increases due to changes in their relative wind (Angle of Attack). Especially for fixed props, smaller, with higher rpm, gave a greater effective thrusting speed range as aircraft design moved beyond the Wrights. Variable pitch props partially solved this issue, enabling another leap forward to higher speeds, but now power output became more of an issue as 2x speed meant 4x drag leading to:
Multiple engines turning multiple props, which also improved safety in case one engine failed.
Further improvements in power output lead to: more blades on props.
Still more power from jet turbines: many bladed fans.
Both with lower thrusting efficiency but much more thrust output and greater speed range than 2 blade props.
So, could a turbo fan have 2 adjacent fans? Increases in reliability and greater power producing efficiency certainly has started a trend towards fewer, larger jet engines with bigger fans. One giant turbine running 2 fans? Possible.
One giant turbine generating electricity for 4 fans? Aha! No mechanical linkages needed!
But, especially for large passenger aircraft, going with less than 2 power plants will be unlikely in the near future, unless it's a zeppelin.