It's Paine Field (KPAE) in Seattle. It has both 16L and 16R and has water (the Puget Sound) directly ahead if you're taking off from the 34s. 34L is also the only runway there large enough for most jet traffic, so that's what a Delta jet would be using if it were there.
It's also worth noting that this commercial is about flight testing and Paine Field just so happens to be the home of an aircraft production facility for some little company named 'Boeing.' You can see their Everett Production Facility on the North side of the airport in the Google Earth view and the aerial photo below. Interesting fact: that facility, originally built in 1967 to produce the Boeing 747, remains the largest building in the world by volume even to today. It's 79% larger than the next largest building and a full 3.63 times the size of NASA's Vehicle Assembly Building, the previous largest building in the world by volume, where NASA performed final integration of the Saturn V and Space Shuttle stacks and where it will do so for the SLS.
Here's the Google Earth view, and it looks like the two islands on the left in the commercial are Hat Island and Camano Island:
Sectional Chart Showing KPAE
Aerial View of Paine Field - Source: Wikipedia
Honestly, the claim of there only being 1 airport with any given runway number seems rather suspicious, since there are only 18 possibilities. Granted, the requirement of having parallel runways makes it a little less unlikely, but still many (if not most) large airports have parallel runways.