At $10,680 m$ cruising altitude air pressure is $23.8 kPa$ / $3.45psi$ / $23,800 N/m²$; compared to $101kPa$ / $14.7psi$ / $101,000 N/m^2$ at sea level.
Now a 747 for example has a pressurization altitude of $2,440m$ which equates to an internal pressure of $75kPa$ / $10.9psi$ and a force of $75,000 N/m^2$.
So the internal pressure of $75,000 N/m^2 - 23,800 N/m^2 = 51,200 N/m^2$
Door dimensions are $1.93m (H) \times 1.07m (W) = 2.07m^2$
Or in feet & inches: $6'4" (H) \times 3'6" (W) = 22.17 sqft$
So $51,200 N/m^2 \times 2.0651m^2 = 105,733.12 N$
Which equates to roughly 11.88 Metric Tonnes of force on the inside of the door! The door being larger than outside portal of the door. It is forced into the frame with considerable pressure. It would be impossible for a human to operate the door under that force.