So, is the L/D [of] a cruising aircraft best when bottom is concave?
If we use gliders as a reference, the bottom of the best airfoils is only very slightly concave, almost straight, in order to allow for a long laminar run while still achieving high lift. Up to the Nineties of the last century, the best designs used rear loading over the last 15% - 20% while the most recent ones do away with even that to squeeze a few percent more of laminarity from the lower side. This has to do with flying technique as well as better understanding of laminar flow: Instead of optimizing the design for two polar points (thermalling and fast flight), now the ideal is to also look at intermediate speeds like when flying under lined-up clouds.
While birds have wings optimized for low speed because they can retract and fold their wings when going fast, airplanes have to design their wings for high speed and add flaps and slats for low speed flight. When you look at an airfoil of an airliner in landing configuration, it is not so different from a bird's wing.
Typical landing configuration of an airliner wing, from an article by A. M. O. Smith, McDonnell-Douglas, in Journal of Aircraft, Vol 12 No 6, 1975.
Also, birds do not have to deal with trans- and supersonic effects which dictate the airfoil shape of almost all jet-powered airplanes.
Curiously, the propeller, which also has similar conditions, has a convex bottom.
Propeller and especially rotor airfoils should have a low pitching moment change over angle of attack to avoid twisting the propeller rsp. rotor blade. This is achieved by reduced camber, and the result is a convex bottom surface: A symmetrical airfoil has no pitching moment variation within the linear range of angles of attack. In order to be able to work over a range of angles of attack, they must have a certain thickness, which of course also benefits the structure.