Here's a rule of thumb: you can assume that the range of a practical electric aircraft, in nautical miles, is approximately equal to the energy density of its batteries, in Wh/kg. Today, that number is about 250, tops.
That rule of thumb assumes that the cruise L/D is 20:1. If your design gets 10:1, halve the range.
Is 20:1 realistic? Well, a Cirrus SR22, a modern all-composite airplane, gets about 17 at a best L/D around 90 kt. So, 20:1 is ambitious, but realistic.
If your idea of "practical" is a 160 kt cruise speed, you'll need an airframe with an L/D of 20:1 at 160 kt, that also has a big enough wing to slow down to 60 kt as required by Part 23. That's hard. Or, you can get 10:1 at 160 kt, meet Part 23 requirements, but halve the range.
If your idea of "practical" is a range of 600 NM, you'll need batteries with 600 Wh/kg. They don't exist.
If 90 kt cruise for 250 NM is your idea of "practical", the technology is good enough today. And, 120 kt cruise for 250 NM may be feasible with clever airframe design.
Let's turn to the system engineering behind this answer.
Energy required = Force x Distance = Drag x Range = [Weight / (L/D)] x Range = Energy stored in the batteries
$E_{req}= F \cdot x = D \cdot R = \frac {W\cdot D}{L}\cdot R = E_{bat}$
With:
- $E_{req}$ = energy required
- $F$ = force
- $x$ = displacement
- $D$ = aerodynamic drag
- $R$ = range
- $W$ = weight
- $L$ = lift
- $E_{bat}$ = energy from the battery
So,
$R \approx \frac{ E_{bat}}{W}\cdot \frac{L}{D}$
Weight = Payload + Electric power system weight + structural weight
For a practical aircraft, the structural weight is approximately half of the total weight, maybe a little less. Let's call it 0.5 if we include the weight of the electric motor, which will scale with the aircraft weight.
So, if the structure including the motor is half the total weight, we have
$W \approx 2 (W_{payload} + W_{bat})$
Let's define $k$ as the fraction of the lifted weight (i.e., Payload + Battery) that is battery.
So, $k = \frac{W_{bat}}{W_{payload}+W_{bat}}$, and therefore $W_{payload} + W_{bat} = \frac{W_{bat}}{k}$.
So,
$W \approx \frac{2 \cdot W_{bat}} { k}$
Then,
$R \approx \frac{E_{bat}}{ W_{bat} }\cdot\frac{k}{2} \cdot \frac{L}{D} $
This needs one adjustment: the energy available from the battery in practice is not $W_{bat}$, but rather $U \cdot W_{bat}$, where $U$ has a value of about 75%. This is because if you fully charge and discharge the battery on each cycle, using the full amount of $W_{bat}$, the battery will not last for many cycles.
So, we adjust to show
$R \approx \frac{E_{bat}}{ W_{bat} }\cdot\frac{k}{2} \cdot U \cdot \frac{L}{D} $
Now, that's all in SI units, where Distance is in meters, energy is in joules, and weight is in Newtons (not kg!). Let's do a unit conversion:
$R = 1852 \cdot R_{NM}$
$E = 3600 \cdot E_{Wh}$
$W_{bat} = 9.8 \cdot M_{bat, kg}$
So,
$1852 \cdot R_{NM} \approx \frac{3600 \cdot E_{Wh}}{ 9.8 \cdot M_{bat, kg} }\cdot\frac{k}{2} \cdot U \cdot \frac{L}{D} $
and thus
$R_{NM} \approx \ 0.0743 \cdot \frac{E_{Wh}}{M_{bat, kg} }\cdot\ k \cdot \frac{L}{D} $
or, if we assume $\frac{L}{D} \approx 20$
then
$R_{NM} \approx \ 1.48 \cdot\ k \cdot \frac{E_{Wh}}{M_{bat, kg} }$
The maximum possible range is if $k = 1$, i.e., there's no payload, and the aircraft carries nothing but battery.
But, for a more practical design, if we set $k = \frac{1}{1.48} = 0.67$, i.e., the battery weighs twice times as much as the payload (think of it as 200 kg of battery, or 440 lb of battery, per person carried), then
$R_{NM} \approx \frac{E_{Wh}}{M_{bat, kg} }$
Which is the rule of thumb: range in nautical miles equals energy density in Wh/kg.
More precisely,
$R_{NM} \approx \frac{E_{Wh}}{M_{bat, kg}} \cdot \frac{\frac{L}{D}}{20}$
You could add more range by having a bigger battery fraction k, but going from battery weight of 2 x payload to 4 x payload only adds 20% to range - not very exciting.
Note that the basic rule of thumb assumes quite a high $\frac{L}{D}$ ratio of 20:1 in cruise. Note also that it says nothing about speed or altitude flown: ultimately, all that matters, for range, is cruising $\frac{L}{D}$ and battery energy density.